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Somatic SNCA Copy Number Variants in Multiple System Atrophy are Related to Pathology and Inclusions

30 Nov 2022

Abstract excerpt

BACKGROUND: Somatic α-synuclein (SNCA) copy number variants (CNVs, specifically gains) occur in multiple system atrophy (MSA) and Parkinson's disease brains. OBJECTIVE: The aim was to compare somatic SNCA CNVs in MSA subtypes (striatonigral degeneration [SND] and olivopontocerebellar atrophy [OPCA]) and correlate with inclusions. METHODS: We combined fluorescent in situ hybridization with immunofluorescence for...

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PMID: 36448620
DOI: 10.1002/mds.29291

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