Article

Oligodendroglial somatic SNCA copy number gains are associated with inclusions and disease onset in multiple system atrophy

2026-01-30

Abstract excerpt

<title>Abstract</title> <p> Multiple system atrophy (MSA) is a rapidly progressive synucleinopathy of unknown aetiology with neuronal and oligodendroglial α-synuclein inclusions. We previously reported somatic copy number variants (CNVs), specifically gains, of <italic>SNCA</italic> (encoding α-synuclein) in MSA brains. Here, we expand on this work by combining fluorescent <italic>in situ</italic> hybridisat...

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Literature Corpus work: f9e8e9cf-5615-5db5-8ed9-24445d9b005f
DOI: 10.21203/rs.3.rs-8701777/v1

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