Article

Investigation of somatic mutations in human brains targeting genes associated with Parkinson’s disease

2020-05-18

Abstract excerpt

<h4>Background</h4> Somatic mutations occur in neurons but their role in synucleinopathies is unknown. <h4>Aim</h4> We aimed to identify disease-relevant low-level somatic single nucleotide variants (SNVs) in brains from sporadic patients with synucleinopathies and a monozygotic twin carrying LRRK2 G2019S, whose penetrance could be explained by somatic variation. <h4>Methods and Results</h4> We included different...

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Literature Corpus work: 27b2a03d-8113-513a-9286-21ecdd42e335
DOI: 10.1101/2020.05.15.20094722

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