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Article

Clonal hematopoiesis with DNMT3A mutations is associated with multiple system atrophy.

Parkinsonism & related disorders - 1 Nov 2024

Lee Seungmin, Kim Han-Joon, Kim Seoyeon, Jin Bora, Jeon HoYoung, Woo Kyung Ah, Shin Jung Hwan, Lee Chansub, Sun Choonghyun, Im Hogune, An Hongyul, Koh Young Il, Choi Su-Yeon, Jeon Beomseok

Abstract excerpt

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP) is associated with cardiovascular diseases and other disorders, possibly via inflammation. Recent research suggests a connection of CHIP with neurodegenerative disorders. OBJECTIVE: We aimed to investigate the association between multiple system atrophy (MSA) and CHIP. METHODS: We included 100 patients with MSA and 4457 controls. Targeted...

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Identifiers

PMID: 39278121
DOI: 10.1016/j.parkreldis.2024.107145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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