Article

The necessity of incorporating non-genetic risk factors into polygenic risk score models

2022-06-22

Abstract excerpt

The growing public interest in genetic risk scores for various health conditions may inspire preventive health action. However, these risk scores can be deceiving as they do not consider other, easily attainable risk factors, such as sex, BMI, age, smoking habits, parental disease status and physical activity. We show improved performance in identifying the 10% most at-risk individuals for type 2 diabetes (T2D) an...

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Literature Corpus work: 0f91906c-0e96-5f70-bc57-c1b622d4ddb4
DOI: 10.21203/rs.3.rs-1691718/v1

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