Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes.

Communications biology - 23 Feb 2022

Tamlander Max, Mars Nina, Pirinen Matti, Widén Elisabeth, Ripatti Samuli

Abstract excerpt

Large-scale biobank initiatives and commercial repositories store genomic data collected from millions of individuals, and tools to leverage the rapidly growing pool of health and genomic data in disease prevention are needed. Here, we describe the derivation and validation of genomics-enhanced risk tools for two common cardiometabolic diseases, coronary heart disease and type 2 diabetes. Data used for our...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Disease Management Strategies
Share to Coronary Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes, Cardiovascular Risks, and Lipoproteins

Share to Diabetes Mellitus, Type 2

Share to Genetic Associations and Epidemiology

Share to Genetic Predisposition to Disease

Share to Risk Factors

Share to Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 35197564
DOI: 10.1038/s42003-021-02996-0
PMCID: PMC8866413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integration of questionnaire-based risk factors improves polygenic risk scores for human coronary heart disease and type 2 diabetes.PMID 35197564Read ↗

The necessity of incorporating non-genetic risk factors into polygenic risk score models.Semantic proximity Read ↗

The necessity of incorporating non-genetic risk factors into polygenic risk score modelsSemantic proximity Read ↗

An integrated polygenic and clinical risk tool enhances coronary artery disease predictionSemantic proximity Read ↗

Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction.Semantic proximity Read ↗

Incorporating polygenic risk into the Leicester Risk Assessment score for 10-year risk prediction of type 2 diabetes.Semantic proximity Read ↗

Integration of biomarker polygenic risk score improves prediction of coronary heart disease in UK Biobank and FinnGenSemantic proximity Read ↗

Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers.Semantic proximity Read ↗

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular Risk Collaboration, and the European Association of Preventive CardiologySemantic proximity Read ↗

Combining stacked polygenic scores with clinical risk factors improves cardiovascular risk prediction in people with type 2 diabetesSemantic proximity Read ↗

Advancing cardiovascular disease risk prediction beyond conventional methods: a systematic review of multimodal machine learning models integrating traditional clinical factors and multi-omics dataSemantic proximity Read ↗

Bridging traditional risk factors and genetic insights: A review on polygenic risk scores in cardiovascular diseasesSemantic proximity Read ↗

Harnessing Whole Genome Polygenic Risk Scores to Stratify Individuals Based on Cardiometabolic Risk Factors and Biomarkers at Age 10 in the Lifecourse-Brief Report.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.