Article
The necessity of incorporating non-genetic risk factors into polygenic risk score models.
Scientific reports - 20 Feb 2023
van Dam Sipko, Folkertsma Pytrik, Castela Forte Jose, de Vries Dylan H, Herrera Cunillera Camila, Gannamani Rahul, Wolffenbuttel Bruce H R
Abstract excerpt
The growing public interest in genetic risk scores for various health conditions can be harnessed to inspire preventive health action. However, current commercially available genetic risk scores can be deceiving as they do not consider other, easily attainable risk factors, such as sex, BMI, age, smoking habits, parental disease status and physical activity. Recent scientific literature shows that adding these...
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