Article

Single cell transcriptome analysis of decidua macrophages in normal and recurrent spontaneous abortion patients

2021-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Due to the heterogeneity and different polarization state of decidual macrophages (dMΦ), they play an important role during the pregnancy, but their definition and exact function remain elusive. We isolated CD14 + CD45 + dMΦ from the normal or RSA decidua by flow cytometry, followed by single cell RNA sequencing (scRNA-seq). In total, 23,062 single-cell transcriptomes of macrophage were profil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c5aa37e3-d21d-5f5e-b9da-44c7f61335f4
DOI: 10.1101/2021.03.23.436615

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single cell transcriptome analysis of decidua macrophages in normal and recurrent spontaneous abortion patientsDOI 10.1101/2021.03.23.436615Read

Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortionSemantic proximity Read

Identification and validation of a signature based on macrophage cell marker genes to predict recurrent miscarriage by integrated analysis of single-cell and bulk RNA-sequencingSemantic proximity Read

A comprehensive cell profiling reveals new cell subtypes and immune dysfunction in peritoneal fluid of endometriosisSemantic proximity Read

Decidual macrophage subsets and polarization puzzle during the human early pregnancySemantic proximity Read

The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy LossSemantic proximity Read

Cell subtypes and immune dysfunction in peritoneal fluid of endometriosis revealed by single-cell RNA-sequencingSemantic proximity Read

Computational flow cytometry analysis reveals a unique immune signature of the human maternal‐fetal interfaceSemantic proximity Read

Integrated analysis of single-cell and bulk transcriptomic data reveals altered cellular composition and predictive cell types in endometriosisSemantic proximity Read

Integrating single-cell RNA sequencing with spatial transcriptomics reveals immune landscape for interstitial cystitisSemantic proximity Read

Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneitySemantic proximity Read

Uncovering the Gene Regulatory Networks Underlying Macrophage Polarization Through Comparative Analysis of Bulk and Single-Cell DataSemantic proximity Read

Dysfunction of CCR1+ decidual macrophages is a potential risk factor in the occurrence of unexplained recurrent pregnancy lossSemantic proximity Read