Article

Machine learning reveals limited contribution of trans-only encoded variants to the HLA-DQ immunopeptidome by accurate and comprehensive HLA-DQ antigen presentation prediction

2022-09-17

Abstract excerpt

HLA class II antigen presentation is key for controlling and triggering T cell immune responses. HLA-DQ molecules, which are believed to play a major role in autoimmune diseases, are heterodimers that can be formed as both cis and trans variants depending on whether the α- and β-chains are encoded on the same (cis) or opposite (trans) chromosomes. So far, limited progress has been made for predicting HLA-DQ antige...

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Literature Corpus work: 0f745d07-9a68-5449-b5d8-6d48328d3fdd
DOI: 10.1101/2022.09.14.507934

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