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Article

Landscape of somatic mutations in aging human heart muscle cells.

Nature aging - 1 Aug 2022

Walsh Christopher, Choudhury Sangita, Chen Ming Hui

Abstract excerpt

Using single-cell whole-genome sequencing, we identified and characterized the landscape of somatic single-nucleotide variants (sSNVs) in single cardiomyocytes from individuals across the human lifespan. Aged cardiomyocytes were found to have a higher burden of sSNVs and show mutational signatures that suggest failed repair of oxidative DNA damage.

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Identifiers

PMID: 36471785
DOI: 10.1038/s43587-022-00264-2
PMCID: PMC9719721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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