Article

High- versus low-dose dietary n-3 PUFA treatment produces mixed effects on DNA methylation and epigenetic fidelity in breast adipose tissue

2026-03-22

Abstract excerpt

Long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs) are candidate preventive agents for breast cancer. With emerging evidence of epigenetic regulation of the tumor microenvironment, tissue-level epigenetic effects may represent an important target for cancer prevention. In a randomized Phase II sub-study (high-dose 5 g/day vs low-dose 1 g/day for 12 months; n = 17; Clinicaltrials.gov : NCT02295059 ), DNA meth...

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Literature Corpus work: 0f6fac35-495b-5c88-887b-b8a7512deb63
DOI: 10.64898/2026.03.18.26348746

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