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DNA methylation and breast cancer-associated variants.

Breast cancer research and treatment - 1 Aug 2021

Ho Peh Joo, Dorajoo Rajkumar, Ivanković Ivna, Ong Seeu Si, Khng Alexis Jiaying, Tan Benita Kiat-Tee, Tan Veronique Kiak Mien, Lim Swee Ho, Tan Ern Yu, Tan Su-Ming, Tan Qing Ting, Yan Zhiyan, Ngeow Joanne, Sim Yirong, Chan Patrick, Chuan Juliana Chen Jia, Chan Ching Wan, Tang Siau Wei, Hartman Mikael, Li Jingmei

Abstract excerpt

BACKGROUND: A breast cancer polygenic risk score (PRS) comprising 313 common variants reliably predicts disease risk. We examined possible relationships between genetic variation, regulation, and expression to clarify the molecular alterations associated with these variants. METHODS: Genome-wide methylomic variation was quantified (MethylationEPIC) in Asian breast cancer patients (1152 buffy coats from peripheral...

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PMID: 33768416
DOI: 10.1007/s10549-021-06185-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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