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An Epigenetic Signature in Adipose Tissue Is Linked to Nicotinamide N‐Methyltransferase Gene Expression

24 Apr 2018

Abstract excerpt

Scope The enzyme nicotinamide N‐methyltransferase (NNMT) is a major methyltransferase in adipose tissue. We hypothesized an epigenetic signature in association with NNMT gene expression in adipose tissue. Methods and results The global human methylome was analyzed in visceral adipose tissue (VAT) from morbidly obese patients using the Infinium Human Methylation 450 BeadChip array (discovery cohort: n = 11). The...

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PMID: 29688621
DOI: 10.1002/mnfr.201700933

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