Article

Single-cell analysis of megakaryopoiesis in peripheral CD34 <sup>+</sup> cells: insights into ETV6-related thrombocytopenia

2022-09-21

Abstract excerpt

Expansion of human megakaryoblasts from peripheral blood-derived CD34 + cells is commonly used to characterize inherited or acquired thrombocytopenia and evaluate defects in megakaryocyte (MK) differentiation, MK maturation and proplatelet formation. We applied single-cell RNA sequencing to understand local gene expression changes during megakaryopoiesis (days 6 and 11 of differentiation) in peripheral CD34 + ce...

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Literature Corpus work: 671dfc47-54ff-5403-a80d-539b3dd2d5f7
DOI: 10.1101/2022.09.20.508634

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