Article

SFRP2 Drives Aerobic Glycolysis and Tumor Progression in Ovarian Cancer via Transcriptional Upregulation of PTK2B

2026-01-16

Abstract excerpt

<title>Abstract</title> <p>Background Ovarian cancer is a highly lethal gynecologic malignancy, with metabolic reprogramming being a key contributor to its progression and therapy resistance. Although Secreted Frizzled-Related Protein 2 (SFRP2) is implicated in cancer, its functional role and molecular mechanisms in ovarian cancer, particularly in regulating metabolic pathways, remain poorly defined. Methods Bi...

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Literature Corpus work: 0f4a9d0a-6fff-5f9c-9b8e-4f0859084744
DOI: 10.21203/rs.3.rs-8553543/v1

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