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Article

Single-cell transcriptome analysis revealed heterogeneity in glycolysis and identified IGF2 as a therapeutic target for ovarian cancer subtypes

31 Jul 2024

Abstract excerpt

BACKGROUND: As the most malignant tumor of the female reproductive system, ovarian cancer (OC) has garnered increasing attention. The Warburg effect, driven by glycolysis, accounts for tumor cell proliferation under aerobic conditions. However, the metabolic heterogeneity linked to glycolysis in OC remains elusive. METHODS: We integrated single-cell data with OC to score glycolysis level in tumor cell...

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Share to Cancer, Hypoxia, and Metabolism
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Share to Single-cell and spatial transcriptomics

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PMID: 39085784
DOI: 10.1186/s12885-024-12688-7

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