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Phosphofructokinase-1 in Cancer: A Promising Target for Diagnosis and Therapy

22 Aug 2024

Abstract excerpt

Tumor cells have distorted enzymatic houses, which change the metabolic state from oxidative phosphorylation to glycolysis with high lactate levels in a hypoxic environment. Redrafting the metabolic profile is an emerging hallmark of cancer. Glycolytic enzyme amplification occurs in about 70% of all malignancies. Current studies have found that PFK-1 overexpression is linked to cell migration, proliferation, and...

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PMID: 39171598
DOI: 10.2174/0115748928321372240813080131

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