Article

GTPBP4 enhances colorectal cancer cell proliferation by activating MYC-driven glycolysis

2025-11-13

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for novel therapeutic targets. GTPBP4, a GTP-binding protein involved in ribosome biogenesis, has been implicated in several cancers, but its role and mechanism in CRC remain unclear. Methods Transcriptomic and clinical data from the TCGA and GEO databases were...

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Literature Corpus work: 14fb327a-0246-58e3-96ca-24d2358113da
DOI: 10.21203/rs.3.rs-7977177/v1

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