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Article

c-Src Promotes Tumorigenesis and Tumor Progression by Activating PFKFB3.

Cell reports - 24 Mar 2020

Ma Huanhuan, Zhang Jia, Zhou Lin, Wen Shixiong, Tang Hsiang-Yu, Jiang Bin, Zhang Fengqiong, Suleman Muhammad, Sun Dachao, Chen Ai, Zhao Wentao, Lin Furong, Tsau Ming-Tong, Shih Lu-Min, Xie Changchuan, Li Xiaotong, Lin Donghai, Hung Li-Man, Cheng Mei-Ling, Li Qinxi

Abstract excerpt

Reprogramming of glucose metabolism is a key event in tumorigenesis and progression. Here, we show that active c-Src stimulates glycolysis by phosphorylating (Tyr194) and activating PFKFB3, a key enzyme that boosts glycolysis by producing fructose-2,6-bisphosphate and activating PFK1. Increased glycolysis intermediates replenish non-oxidative pentose phosphate pathway (PPP) and serine pathway for biosynthesis of...

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PMID: 32209481
DOI: 10.1016/j.celrep.2020.03.005

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