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Article

PFKP is required for chemoresistant phenotype of breast cancer through modulating the formation of CD133+ cancer stem like cells.

Molecular biomedicine - 23 Apr 2026

Fang Kai, Ma Yue, Li Lihua, Yue Yan, Ruan Hang, Xiong Sidong

Abstract excerpt

Breast cancer is the foremost cause of cancer-related death in women globally, and taxane-anthracycline (TA) combination regimens represent standard frontline chemotherapy. Although widely administered, the pathological complete response rate to TA therapy is less than 30%, and chemoresistance remains a major barrier to effective disease control, frequently leading to relapse and poor survival. Both metabolic...

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Share to AC133 Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cancer-Associated Fibroblasts

Share to Cell Line, Tumor

Share to Drug Resistance, Neoplasm

Share to Glycolysis

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Source

Open in PubMed Open full text

Identifiers

PMID: 42024199
DOI: 10.1186/s43556-026-00454-z
PMCID: PMC13106758

Genes

PFKP
CXCL16
CXCR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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