Article

ecDNA amplification of <i>MYC</i> drives intratumor copy-number heterogeneity and adaptation to stress in PDAC

2023-09-29

Abstract excerpt

Intratumor heterogeneity and phenotypic plasticity drive tumour progression and therapy resistance. Oncogene dosage variation contributes to cell state transitions and phenotypic heterogeneity, thereby providing a substrate for somatic evolution. Nonetheless, the genetic mechanisms underlying phenotypic heterogeneity are still poorly understood. Here, we show that extrachromosomal DNA (ecDNA) is a major source of...

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Literature Corpus work: 09d7b001-da6c-51bd-aa39-00a8ab46f00b
DOI: 10.1101/2023.09.27.559717

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