Article

DREAM represses distinct targets by cooperating with different THAP domain proteins

2020-08-14

Abstract excerpt

<h4>ABSTRACT</h4> The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle and other genes, but its mechanism of action is unclear. Here we demonstrate that two C. elegans THAP domain proteins, LIN-15B and LIN-36, co-localize with DREAM and function by different mechanisms for repression of distinct sets of targets. LIN-36 represses classical cell cycle...

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Literature Corpus work: 0f34990e-e700-5430-8b05-431536034ba2
DOI: 10.1101/2020.08.13.249698

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