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Article

Organization of chromosomes in spermatozoa: an additional layer of epigenetic information?

22 May 2007

Abstract excerpt

Elaborate non-random organization of human sperm chromosomes at different structural levels, starting from the DNA packing by protamines up to the higher-order chromosome configuration and nuclear positioning of chromosome territories, has been discovered. Here, we put forward a hypothesis that the unique genome architecture in sperm provides a mechanism for orchestrated unpacking and ordered activation of the...

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Share to Epigenetics and DNA Methylation
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PMID: 17511662
DOI: 10.1042/bst0350609

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