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Mammalian sperm nuclear organization: resiliencies and vulnerabilities

1 Dec 2016

Abstract excerpt

Sperm cells are remarkably complex and highly specialized compared to somatic cells. Their function is to deliver to the oocyte the paternal genomic blueprint along with a pool of proteins and RNAs so a new generation can begin. Reproductive success, including optimal embryonic development and healthy offspring, greatly depends on the integrity of the sperm chromatin structure. It is now well documented that DNA...

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PMID: 28031843
DOI: 10.1186/s12610-016-0044-5

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