Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding.

doi:10.1371/journal.ppat.1013123

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Article

Bat sarbecovirus WIV1-CoV bears an adaptive mutation that alters spike dynamics and enhances ACE2 binding.

PLoS pathogens - 1 Oct 2025

Tse Alexandra L, Lasso Gorka, Berrigan Jacob, McLellan Jason S, Chandran Kartik, Miller Emily Happy

Abstract excerpt

SARS-like betacoronaviruses (sarbecoviruses) endemic in bats pose a significant zoonotic threat to humans. Genetic pathways associated with spillover of bat sarbecoviruses into humans are incompletely understood. We previously showed that the wild-type spike of the rhinolophid bat coronavirus SHC014-CoV has poor entry activity and uncovered two distinct genetic pathways outside the receptor-binding domain (RBD)...

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PMID: 41100556
DOI: 10.1371/journal.ppat.1013123
PMCID: PMC12588501

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ACE2

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