Article

Determinants of species-specific utilization of ACE2 by human and animal coronaviruses

2023-03-31

Abstract excerpt

<h4>ABSTRACT</h4> Utilization of human ACE2 allowed several bat coronaviruses (CoVs), including the causative agent of COVID-19, to infect humans either directly or via intermediate hosts. Here, we analyzed the ability of Spike proteins from 24 human or animal CoVs to use ACE2 receptors across nine reservoir, potential intermediate and human hosts. We show that overall SARS-CoV-2 Omicron variants evolved more eff...

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Literature Corpus work: 9c1ff60d-c712-5463-94c4-31734d86e45c
DOI: 10.1101/2023.03.31.535059

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