Article

Prion protein quantification in cerebrospinal fluid as a tool for prion disease drug development

2018-04-04

Abstract excerpt

Reduction of native prion protein (PrP) levels in the brain is an attractive and genetically validated strategy for the treatment or prevention of human prion diseases. However, clinical development of any PrP-reducing therapeutic will require an appropriate pharmacodynamic biomarker: a practical and robust method for quantifying PrP, and reliably demonstrating its reduction, in the central nervous system (CNS) of...

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Literature Corpus work: 3c074a1d-78b1-5381-9983-4eb179e1f007
DOI: 10.1101/295063

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