Article

Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase

2023-08-01

Abstract excerpt

DNA replication in eukaryotes relies on the synthesis of a ∼30-nucleotide RNA/DNA primer strand through the dual action of the heterotetrameric polymerase α-primase (pol-prim) enzyme. Synthesis of the 7-10-nucleotide RNA primer is regulated by the C-terminal domain of the primase regulatory subunit (PRIM2C) and is followed by intramolecular handoff of the primer to pol α for extension by ∼20 nucleotides of DNA. He...

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Literature Corpus work: 0ebc46bd-a2fb-5a28-b446-e521f5e697e7
DOI: 10.1101/2023.08.01.551538

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