Alterations of PINK1-PRKN signaling in mice during normal aging

Abstract excerpt

<h4>ABSTRACT</h4> The ubiquitin kinase-ligase pair PINK1-PRKN identifies and selectively marks damaged mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this cytoprotective pathway has been extensively studied in vitro upon acute and complete depolarization of mitochondria, the significance of PINK1-PRKN mitophagy in vivo is less well established. Here we used a novel approach to...

Topics

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• Ubiquitin-Protein Ligases
• Animals, Genetically Modified
• Autophagy in Disease and Therapy
• Endoplasmic Reticulum Stress and Disease
• Gene Knockdown Techniques
• Mitochondria, Muscle
• Mitochondrial Function and Pathology
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

853fe04e-1f94-54df-a37e-2c34fa707d90

DOI

10.1101/2024.04.29.591753