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The impact of ER <sup>UPR</sup> on mitochondrial integrity mediated by PDK4

2024-07-12

Abstract excerpt

ER and mitochondrial stress are often interconnected and considered as major contributors to aging as well as neurodegeneration. Co-ordinated induction of ER UPR and mito UPR has been observed in diabetes and pulmonary disorders. However, in the context of aging and neurodegeneration, regulation of this intra-organellar crosstalk has remained relatively elusive. Here, we demonstrate that pyruvate dehydrogenase k...

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Literature Corpus work
ff3f7c14-8165-5a27-8270-75b4636b0fa6
DOI
10.1101/2024.07.12.603217
Open publication

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The impact of ER <sup>UPR</sup> on mitochondrial integrity mediated by PDK4DOI 10.1101/2024.07.12.603217
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