Article

Pharmacologic Activation of Integrated Stress Response Kinases Inhibits Pathologic Mitochondrial Fragmentation

2024-06-10

Abstract excerpt

<h4>SUMMARY</h4> Excessive mitochondrial fragmentation is associated with the pathologic mitochondrial dysfunction implicated in the pathogenesis of etiologically-diverse diseases, including many neurodegenerative disorders. The integrated stress response (ISR) – comprising the four eIF2α kinases PERK, GCN2, PKR, and HRI – is a prominent stress-responsive signaling pathway that regulates mitochondrial morphology...

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Literature Corpus work: f8b76958-7e26-545a-b87b-3473ffaef11a
DOI: 10.1101/2024.06.10.598126

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