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Article

Alterations of PINK1-PRKN signaling in mice during normal aging

7 Dec 2024

Abstract excerpt

The ubiquitin kinase-ligase pair PINK1-PRKN identifies and selectively marks damaged mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this cytoprotective pathway has been extensively studied in vitro upon acute and complete depolarization of mitochondria, the significance of PINK1-PRKN mitophagy in vivo is less well established. Here we used a novel approach to study PINK1-PRKN...

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Share to Autophagy in Disease and Therapy
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PMID: 40008113
DOI: 10.1080/27694127.2024.2434379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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