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A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

2026-05-21

Abstract excerpt

Antibody junctional diversity in jawed vertebrates arose from RAG transposon domestication, generating CDR3-focused V(D)J recombination with lymphocyte specificity—a constrained system limiting engineered antibody diversity. To overcome these limitations, we developed ARESEC ( A ntibody R eprogram and E xpression S ystem in E ngineered C ells), a synthetic platform that enables programmable V(D)J recombinati...

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Literature Corpus work
0eaee9ba-9861-581b-b2e5-6dc3aa9ee759
DOI
10.64898/2026.05.21.726110
Open publication

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A Synthetic Platform for Antibody Junctional Diversification Beyond Natural ConstraintsDOI 10.64898/2026.05.21.726110
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