AbDiver – A tool to explore the natural antibody landscape to aid therapeutic design

Abstract excerpt

<h4>Motivation</h4> Rational design of therapeutic antibodies can be improved by harnessing the natural sequence diversity of these molecules. Our understanding of the diversity of antibodies has recently been greatly facilitated through the deposition of hundreds of millions of human antibody sequences in next-generation sequencing (NGS) repositories. Contrasting a query therapeutic antibody sequence to naturall...

Topics

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• Antibodies, Neutralizing
• Antibody Affinity
• Antigens
• Complementarity Determining Regions
• Glycosylation and Glycoproteins Research
• High-Throughput Nucleotide Sequencing
• Monoclonal and Polyclonal Antibodies Research
• RNA and protein synthesis mechanisms

Identifiers and source

Literature Corpus work

765be034-6157-50ae-8ea7-ff77f7fa98da

DOI

10.1101/2021.11.03.467080