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Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features

2021-10-07

Abstract excerpt

Tumor tissue of origin (TOO) is an important factor for guiding treatment decisions. However, TOO cannot be determined for ~3% of metastatic cancer patients and are categorized as cancers of unknown primary (CUP). As whole genome sequencing (WGS) of tumors is now transitioning from the research domain to diagnostic practice in order to address the increasing demand for biomarker detection, its use for detection of...

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Literature Corpus work
0ea2bbb9-a611-57f9-b6d6-d55caa05b34d
DOI
10.1101/2021.10.05.463244
Open publication

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Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation featuresDOI 10.1101/2021.10.05.463244
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