Article

Cancer of unknown primary: the evolution of tissue of origin identification in the artificial intelligence era

2026-08-10

Abstract excerpt

Cancer of Unknown Primary (CUP) presents substantial diagnostic and therapeutic challenges owing to its heterogeneous nature and the absence of an identifiable primary tumor site. This review provides a structured search of the pathogenesis, epidemiological characteristics, and limitations of traditional diagnostic and therapeutic approaches for CUP, with an emphasis on the evolution of Tissue of Origin (TOO) iden...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: daff4f1d-6c5c-5cf0-beda-3d06f0eb94e1
DOI: 10.1186/s40364-026-00983-3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cancer of unknown primary: the evolution of tissue of origin identification in the artificial intelligence eraDOI 10.1186/s40364-026-00983-3Read

Advances in machine learning for tumour classification in cancer of unknown primary: A mini-review.Semantic proximity Read

Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation featuresSemantic proximity Read

Cancer of unknown primary.Semantic proximity Read

CUP-AI-Dx: A tool for inferring cancer tissue of origin and molecular subtype using RNA gene-expression data and artificial intelligenceSemantic proximity Read

Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation featuresSemantic proximity Read

Machine learning-based tissue of origin classification for cancer of unknown primary diagnostics using genome-wide mutation features.Semantic proximity Read

A comparison of DNA sequencing and gene expression profiling to assist tissue of origin diagnosis in cancer of unknown primarySemantic proximity Read

Machine learning analysis using 77,044 genomic and transcriptomic profiles to accurately predict tumor typeSemantic proximity Read

A prospective national precision medicine trial comparing blood and tissue profiling in patients with Cancer of Unknown Primary (CUPCOMP)Semantic proximity Read

Validation of a transcriptome-based assay for classifying cancers of unknown primary originSemantic proximity Read

Exploring the biological hallmarks of cancer of unknown primary: where do we stand today?Semantic proximity Read

Utilizing Electronic Health Records (EHR) and Tumor Panel Sequencing to Demystify Prognosis of Cancer of Unknown Primary (CUP) patientsSemantic proximity Read