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Article

A machine learning framework to trace tumor tissue-of-origin of 13 types of cancer based on DNA somatic mutation.

Biochimica et biophysica acta. Molecular basis of disease - 1 Nov 2020

He Bingsheng, Dai Chan, Lang Jidong, Bing Pingping, Tian Geng, Wang Bo, Yang Jialiang

Abstract excerpt

Carcinoma of unknown primary (CUP), defined as metastatic cancers with unknown cancer origin, occurs in 3-5 per 100 cancer patients in the United States. Heterogeneity and metastasis of cancer brings great difficulties to the follow-up diagnosis and treatment for CUP. To find the tissue-of-origin (TOO) of the CUP, multiple methods have been raised. However, the accuracies for computed tomography (CT) and positron...

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PMID: 32771416
DOI: 10.1016/j.bbadis.2020.165916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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