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Article

c-Myc directly targets an over-expression of pyruvate carboxylase in highly invasive breast cancer.

Biochimica et biophysica acta. Molecular basis of disease - 1 Mar 2020

Lao-On Udom, Rojvirat Pinnara, Chansongkrow Pakkanan, Phannasil Phatchariya, Siritutsoontorn Siraprapa, Charoensawan Varodom, Jitrapakdee Sarawut

Abstract excerpt

Here we showed that the c-Myc oncogene is responsible for overexpression of pyruvate carboxylase (PC) in highly invasive MDA-MB-231 cells. Pharmacological inhibition of c-Myc activity with 10074-G5 compound, resulted in a marked reduction of PC mRNA and protein, concomitant with reduced cell growth, migration and invasion. This growth inhibition but not migration and invasion can be partly restored by...

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Identifiers

PMID: 31874204
DOI: 10.1016/j.bbadis.2019.165656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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