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SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice

22 Jan 2021

Abstract excerpt

BACKGROUND: -dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we sought to define the role of SIRT6 in BC cell metabolism and in mouse polyoma middle T antigen (PyMT)-driven mammary tumors. METHODS: We evaluated...

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PMID: 33482921
DOI: 10.1186/s40170-021-00240-1

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