Back to search

Article

AAV-mediated <i>CSNK2B</i> gene replacement rescues ASD-relevant phenotypes and establishes EEG biomarkers for translation in <i>Csnk2b</i> haploinsufficient mice

2025-10-24

Abstract excerpt

De novo CSNK2B variants are strongly associated with autism spectrum disorder (ASD) and early-onset epilepsy, yet in vivo therapeutic evidence and translatable biomarkers remain limited. We generated Csnk2b haploinsufficient ( Csnk2b +/– ) mice that recapitulate core clinical features—ASD-like social and cognitive deficits, heightened anxiety, spontaneous seizures, cortical and hippocampal structural compromis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d0ab65a5-8c23-52a8-a1e4-9ca1c327056b
DOI
10.1101/2025.10.23.684260
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
AAV-mediated <i>CSNK2B</i> gene replacement rescues ASD-relevant phenotypes and establishes EEG biomarkers for translation in <i>Csnk2b</i> haploinsufficient miceDOI 10.1101/2025.10.23.684260
CSNK2B gene replacement rescues autism-related phenotypes and establishes translational EEG biomarkers.Semantic proximity
Early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A developmental and epileptic encephalopathySemantic proximity
Kv4.2V404M Mutation Induces Epileptiform Activity and Multiple Behavioral Abnormalities in Heterozygous Knock-in Mice.Semantic proximity
<i>Arid1b</i> haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypesSemantic proximity
Base Editing Rescue of Seizures and SUDEP in <i>SCN8A</i> Developmental Epileptic EncephalopathySemantic proximity
Electroencephalographic insights into variant function and clinical outcomes in<i>SCN2A</i>encephalopathySemantic proximity
Antisense oligonucleotide therapy for SCN2A gain-of-function epilepsySemantic proximity
Autism-related phenotypes in a heterozygous Scn2aR854Q mouse model and their partial rescue via a potassium channel opener.Semantic proximity
Base editing rescues seizures and sudden death in a SCN8A mutation-associated developmental epileptic encephalopathy model.Semantic proximity
Epilepsy and neurobehavioral abnormalities in mice with a <i>KCNB1</i> pathogenic variant that alters conducting and non-conducting functions of K <sub>V</sub> 2.1Semantic proximity
Gene therapies alleviate absence epilepsy associated with <i>Scn2a</i> deficiency in DBA/2J miceSemantic proximity
Neonatal but not juvenile gene therapy reduces seizures and prolongs lifespan in SCN1B–Dravet syndrome miceSemantic proximity
Select a neighboring publication to make it the new centre.