Article

Mrj an Hsp40 family chaperone regulates the oligomerization of Orb2 and long-term memory

2022-10-17

Abstract excerpt

Orb2 the Drosophila homolog of Cytoplasmic polyadenylation element binding protein (CPEB) forms prion-like oligomers. These oligomers consist of Orb2A and Orb2B isoforms and their formation are dependent on the oligomerization of the Orb2A isoform. Drosophila with a mutation diminishing Orb2A’s prion-like oligomerization forms long-term memory but fails to maintain it over time. Since, this prion-like oligomerizat...

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Literature Corpus work: 0e50a61c-b3c2-5583-acdd-a80819d3a4cb
DOI: 10.1101/2022.10.16.512122

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