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Article

Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain.

Neuron - 18 Oct 2012

Krüttner Sebastian, Stepien Barbara, Noordermeer Jasprina N, Mommaas Mieke A, Mechtler Karl, Dickson Barry J, Keleman Krystyna

Abstract excerpt

Long-term memory and synaptic plasticity are thought to require the synthesis of new proteins at activated synapses. The CPEB family of RNA binding proteins, including Drosophila Orb2, has been implicated in this process. The precise mechanism by which these molecules regulate memory formation is however poorly understood. We used gene targeting and site-specific transgenesis to specifically modify the endogenous...

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Identifiers

PMID: 23083740
DOI: 10.1016/j.neuron.2012.08.028
PMCID: PMC3480640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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