Article

Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold

2020-05-21

Abstract excerpt

Functional amyloids are present in a wide variety of organisms ranging from bacteria to humans. Experience-dependent aggregation of the cytoplasmic polyadenylation element-binding (CPEB) prion-like protein to a translationally active state has emerged as a plausible biochemical substrate of long-lasting memories. CPEB aggregation is driven by prion-like domains (PLD) that are highly divergent in sequence across sp...

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Literature Corpus work: 586952e8-62b1-5a9e-9883-0b8c9581fa6a
DOI: 10.1101/2020.05.19.103804

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