Article
The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3.
Neuron - 17 Jun 2015
Fioriti Luana, Myers Cory, Huang Yan-You, Li Xiang, Stephan Joseph S, Trifilieff Pierre, Colnaghi Luca, Kosmidis Stylianos, Drisaldi Bettina, Pavlopoulos Elias, Kandel Eric R
Abstract excerpt
Consolidation of long-term memories depends on de novo protein synthesis. Several translational regulators have been identified, and their contribution to the formation of memory has been assessed in the mouse hippocampus. None of them, however, has been implicated in the persistence of memory. Although persistence is a key feature of long-term memory, how this occurs, despite the rapid turnover of its molecular...
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