Article

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma Cruzi

2020-09-03

Abstract excerpt

The Trypanosoma cruzi ( T. cruzi ) parasite is the cause of Chagas disease, a neglected disease endemic in South America. The life cycle of the T. cruzi parasite is complex and includes transitions between distinct life stages. This change in phenotype (without a change in genotype) could be controlled by epigenetic regulation, and might involve the bromodomain-containing factors 1-5 ( Tc BDF1-5). However, lit...

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Literature Corpus work: 0e4b036b-e473-594d-996d-6558d855e02c
DOI: 10.26434/chemrxiv.12897086.v1

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