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Chemical inhibition of bromodomain proteins in insect stage African trypanosomes perturbs silencing of the Variant Surface Glycoprotein repertoire and results in widespread changes in the transcriptome

2023-01-09

Abstract excerpt

The eukaryotic protozoan parasite Trypanosoma brucei, spp . is transmitted by the tsetse fly to both humans and animals, where it causes a fatal disease called African trypanosomiasis. While the parasite lacks canonical DNA sequence specific transcription factors, it does possess histones, histone modifications, and proteins that write, erase, and read histone marks. Chemical inhibition of chromatin interacting b...

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Literature Corpus work
a6470eca-ad36-5b7e-b972-6a6e23b0a1f0
DOI
10.1101/2023.01.09.523188
Open publication

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Chemical inhibition of bromodomain proteins in insect stage African trypanosomes perturbs silencing of the Variant Surface Glycoprotein repertoire and results in widespread changes in the transcriptomeDOI 10.1101/2023.01.09.523188
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