Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of bromodomain factor 3 in Trypanosoma cruzi (TcBDF3) affects differentiation of the parasite and protects it against bromodomain inhibitors.

The FEBS journal - 1 Jun 2016

Alonso Victoria Lucia, Ritagliati Carla, Cribb Pamela, Cricco Julia Alejandra, Serra Esteban Carlos

Abstract excerpt

The bromodomain is the only protein domain known to bind acetylated lysine. In the last few years many bromodomain inhibitors have been developed in order to treat diseases such as cancer caused by aberrant acetylation of lysine residues. We have previously characterized Trypanosoma cruzi bromodomain factor 3 (TcBDF3), a bromodomain with an atypical localization that binds acetylated α-tubulin. In the present...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Antiprotozoal Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Life Cycle Stages

Share to Protein Domains

Share to Protozoan Proteins

Share to Trypanosoma cruzi

Share to Trypanosomiasis

Share to Tubulin

Source

Identifiers

PMID: 27007774
DOI: 10.1111/febs.13719

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of bromodomain factor 3 in Trypanosoma cruzi (TcBDF3) affects differentiation of the parasite and protects it against bromodomain inhibitors.PMID 27007774Read ↗

Essential Bromodomain Tc BDF2 as a Drug Target against Chagas DiseaseSemantic proximity Read ↗

Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic FormsSemantic proximity Read ↗

The bromodomain protein Bdf3 is sufficient to activate expression of a procyclin gene in bloodstream stage African trypanosomesSemantic proximity Read ↗

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the TranscriptomeSemantic proximity Read ↗

Genomic occupancy of the bromodomain protein Bdf3 is dynamic during differentiation of African trypanosomes from bloodstream to procyclic formsSemantic proximity Read ↗

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma CruziSemantic proximity Read ↗

Recognition of hyperacetylated N-terminus of H2AZ by TbBDF2 from Trypanosoma bruceiSemantic proximity Read ↗

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruziSemantic proximity Read ↗

Chemical inhibition of bromodomain proteins in insect stage African trypanosomes perturbs silencing of the Variant Surface Glycoprotein repertoire and results in widespread changes in the transcriptomeSemantic proximity Read ↗

Bromodomain Factor 5 as a Target for Antileishmanial Drug DiscoverySemantic proximity Read ↗

Structural insights into acetylated histone ligand recognition by the BDP1 bromodomain of Plasmodium falciparumSemantic proximity Read ↗

Structural Insights into Bromodomain-Containing Complexes from <i>Trypanosoma cruzi</i> Revealed by Proximity Labeling and Stoichiometric Space ExplorationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.