Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi

17 Nov 2020

Abstract excerpt

The Trypanosoma cruzi ( T. cruzi ) parasite is the cause of Chagas disease, a neglected disease endemic in South America. The life cycle of the T. cruzi parasite is complex and includes transitions between distinct life stages. This change in phenotype (without a change in genotype) could be controlled by epigenetic regulation, and might involve the bromodomain-containing factors 1–5 ( Tc BDF1–5). However, little...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Protein Degradation and Inhibitors
Share to Trypanosoma species research and implications
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33203208
DOI: 10.1021/acsinfecdis.0c00618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruziPMID 33203208Read ↗

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma CruziSemantic proximity Read ↗

Essential Bromodomain Tc BDF2 as a Drug Target against Chagas DiseaseSemantic proximity Read ↗

Genomic Occupancy of the Bromodomain Protein Bdf3 Is Dynamic during Differentiation of African Trypanosomes from Bloodstream to Procyclic FormsSemantic proximity Read ↗

Bromodomain Factor 5 as a Target for Antileishmanial Drug DiscoverySemantic proximity Read ↗

The bromodomain protein Bdf3 is sufficient to activate expression of a procyclin gene in bloodstream stage African trypanosomesSemantic proximity Read ↗

Genomic occupancy of the bromodomain protein Bdf3 is dynamic during differentiation of African trypanosomes from bloodstream to procyclic formsSemantic proximity Read ↗

Overexpression of bromodomain factor 3 in Trypanosoma cruzi (TcBDF3) affects differentiation of the parasite and protects it against bromodomain inhibitors.Semantic proximity Read ↗

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the TranscriptomeSemantic proximity Read ↗

Structural Insights into Bromodomain-Containing Complexes from <i>Trypanosoma cruzi</i> Revealed by Proximity Labeling and Stoichiometric Space ExplorationSemantic proximity Read ↗

Chemical inhibition of bromodomain proteins in insect stage African trypanosomes perturbs silencing of the Variant Surface Glycoprotein repertoire and results in widespread changes in the transcriptomeSemantic proximity Read ↗

Identification of clinically approved small molecules that inhibit growth and promote surface remodeling in the African trypanosomeSemantic proximity Read ↗

Reliable, scalable functional genetics in bloodstream-form Trypanosoma congolense in vitro and in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.