Article

Identification of clinically approved small molecules that inhibit growth and promote surface remodeling in the African trypanosome

2019-09-20

Abstract excerpt

Trypanosoma brucei are unicellular parasites endemic to Sub-Saharan Africa that cause fatal disease in humans and animals. Infection with these parasites is caused by the bite of the tsetse fly vector, and parasites living extracellularly in the blood of infected animals evade the host immune system through antigenic variation. Existing drugs for Human and Animal African Trypanosomiasis are difficult to administer...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b581c3ea-08d0-5972-a28e-0a2d70abbeda
DOI: 10.1101/776658

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of clinically approved small molecules that inhibit growth and promote surface remodeling in the African trypanosomeDOI 10.1101/776658Read

A Brief Review of Drug Discovery Research for Human African TrypanosomiasisSemantic proximity Read

High-throughput chemical screening for antivirulence developmental phenotypes in Trypanosoma brucei.Semantic proximity Read

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasisSemantic proximity Read

Chemical Inhibition of Bromodomain Proteins in Insect-Stage African Trypanosomes Perturbs Silencing of the Variant Surface Glycoprotein Repertoire and Results in Widespread Changes in the TranscriptomeSemantic proximity Read

Chemical inhibition of bromodomain proteins in insect stage African trypanosomes perturbs silencing of the Variant Surface Glycoprotein repertoire and results in widespread changes in the transcriptomeSemantic proximity Read

A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in <i>Trypanosoma congolense</i>Semantic proximity Read

The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targetsSemantic proximity Read

Novel Minor Groove Binders Cure Animal African Trypanosomiasis in an in Vivo Mouse ModelSemantic proximity Read

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.Semantic proximity Read

Mechanisms of life cycle simplification in African trypanosomes.Semantic proximity Read

A <i>Trypanosoma brucei</i> ORFeome-based Gain-of-Function Library identifies genes that promote survival during melarsoprol treatmentSemantic proximity Read

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3Semantic proximity Read