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The high persister phenotype of <i>Pseudomonas aeruginosa</i> is associated with increased fitness and persistence in cystic fibrosis airways

2019-02-27

Abstract excerpt

Despite intensive antibiotic treatment of cystic fibrosis (CF) patients, Pseudomonas aeruginosa often persists in patient airways for decades, and can do so without the development of antibiotic resistance. Using a high-throughput screening assay of survival after treatment with high concentrations of ciprofloxacin, we have determined the prevalence of high-persister variants (Hip) in a large patient cohort. In a...

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Literature Corpus work
0e484ca2-2cb1-5ecc-8812-3c1e13c0fb41
DOI
10.1101/561589
Open publication

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The high persister phenotype of <i>Pseudomonas aeruginosa</i> is associated with increased fitness and persistence in cystic fibrosis airwaysDOI 10.1101/561589
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